Bisacodyl Nizhpharm

Bisacodyl Nizhpharm may be available in the countries listed below.

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Bisacodyl

Bisacodyl is reported as an ingredient of Bisacodyl Nizhpharm in the following countries:

• Latvia

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Isonicid

Isonicid may be available in the countries listed below.

Ingredient matches for Isonicid

Isoniazid

Isoniazid is reported as an ingredient of Isonicid in the following countries:

• Ethiopia


• Hungary

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Brealin

Brealin may be available in the countries listed below.

Ingredient matches for Brealin

Captopril

Captopril is reported as an ingredient of Brealin in the following countries:

• Japan

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Topira-Q

Topira-Q may be available in the countries listed below.

Ingredient matches for Topira-Q

Topiramate

Topiramate is reported as an ingredient of Topira-Q in the following countries:

• Germany

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Kedacillin

Kedacillin may be available in the countries listed below.

Ingredient matches for Kedacillin

Sulbenicillin

Sulbenicillin sodium salt (a derivative of Sulbenicillin) is reported as an ingredient of Kedacillin in the following countries:

• Indonesia


• Mexico

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Paroxetin Stada

Paroxetin Stada may be available in the countries listed below.

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Paroxetine

Paroxetine hydrochloride (a derivative of Paroxetine) is reported as an ingredient of Paroxetin Stada in the following countries:

• Finland


• Germany


• Romania

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Ergometrin

Ergometrin may be available in the countries listed below.

Ingredient matches for Ergometrin

Ergometrine

Ergometrine maleate (a derivative of Ergometrine) is reported as an ingredient of Ergometrin in the following countries:

• Bosnia & Herzegowina


• Slovenia

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Golafair

Golafair may be available in the countries listed below.

Ingredient matches for Golafair

Cetylpyridinium

Cetylpyridinium chloride (a derivative of Cetylpyridinium) is reported as an ingredient of Golafair in the following countries:

• Italy

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Ketokonazol Alternova

Ketokonazol Alternova may be available in the countries listed below.

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Ketoconazole

Ketoconazole is reported as an ingredient of Ketokonazol Alternova in the following countries:

• Sweden

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Paxéladine

Paxéladine may be available in the countries listed below.

Ingredient matches for Paxéladine

Oxeladin

Oxeladin citrate (a derivative of Oxeladin) is reported as an ingredient of Paxéladine in the following countries:

• France

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Ciproterona Generis

Ciproterona Generis may be available in the countries listed below.

Ingredient matches for Ciproterona Generis

Cyproterone

Cyproterone 17α-acetate (a derivative of Cyproterone) is reported as an ingredient of Ciproterona Generis in the following countries:

• Portugal

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Retirides

Retirides may be available in the countries listed below.

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Tretinoin

Tretinoin is reported as an ingredient of Retirides in the following countries:

• Spain

International Drug Name Search

Psoraffect

Psoraffect may be available in the countries listed below.

Ingredient matches for Psoraffect

Calcipotriol

Calcipotriol is reported as an ingredient of Psoraffect in the following countries:

• Greece

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Migea

Migea may be available in the countries listed below.

Ingredient matches for Migea

Tolfenamic Acid

Tolfenamic Acid is reported as an ingredient of Migea in the following countries:

• Czech Republic


• Greece


• Norway


• Poland

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Acarsan

Acarsan may be available in the countries listed below.

Ingredient matches for Acarsan

Benzyl Benzoate

Benzyl Benzoate is reported as an ingredient of Acarsan in the following countries:

• Brazil

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Celiprolol-CT

Celiprolol-CT may be available in the countries listed below.

Ingredient matches for Celiprolol-CT

Celiprolol

Celiprolol hydrochloride (a derivative of Celiprolol) is reported as an ingredient of Celiprolol-CT in the following countries:

• Germany

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Panconium

Panconium may be available in the countries listed below.

Ingredient matches for Panconium

Pancuronium

Pancuronium Bromide is reported as an ingredient of Panconium in the following countries:

• India

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Amikan

Amikan may be available in the countries listed below.

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Amikacin

Amikacin sulfate (a derivative of Amikacin) is reported as an ingredient of Amikan in the following countries:

• Greece


• Italy

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Protofen

Protofen may be available in the countries listed below.

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Ketoprofen

Ketoprofen is reported as an ingredient of Protofen in the following countries:

• Indonesia

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Idroquark

Idroquark may be available in the countries listed below.

Ingredient matches for Idroquark

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Idroquark in the following countries:

• Italy

Ramipril

Ramipril is reported as an ingredient of Idroquark in the following countries:

• Italy

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Fluocinonide

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

C05AA11,D07AC08

CAS registry number (Chemical Abstracts Service)

0000356-12-7

Chemical Formula

C26-H32-F2-O7

Molecular Weight

494

Therapeutic Categories

Dermatological agent

Adrenal cortex hormone, glucocorticoid

Chemical Name

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11ß,16α)-

Foreign Names

• Fluocinonidum (Latin)
• Fluocinonid (German)
• Fluocinonide (French)
• Fluocinonida (Spanish)

Generic Names

• Fluocinonide (OS: USAN, JAN, DCIT, DCF, BAN)
• Fluocinolide (IS)
• Fluocinolone Acetonide 21-Acetate (IS)
• Fluocinonide (PH: JP XIV, USP 32, BP 2010)

Brand Names

• Bestasone
  Ikeda Yakuhin, Japan



• Biscosal
  Teikoku Seiyaku, Japan



• Cortema
  Pharmaderm, Tunisia



• Floremet
  Pascual, Philippines



• Fluocinonide
  Actavis, United States; Fougera, United States; Nycomed, United States; Taro, United States; Teva USA, United States; Tianjin, Myanmar



• Fluskin
  Opalia, Tunisia



• Glycobase
  Mayado Seiyaku, Japan



• Hakelon
  Tatsumi Kagaku, Japan



• Jelliproct (Fluocinonide and Lidocaine)
  Grünenthal, Germany



• Lidex
  Medicis, United States; Minerva, Greece



• Lyderm
  Taro, Canada



• Medrexim
  Taiyo Pharmaceutical, Japan



• Metosyn
  Bioglan, Denmark; Bioglan Pharma, Norway; GP Pharma, United Kingdom



• Novoter Gentamicina (Fluocinonide and Gentamicin)
  Teofarma, Spain



• Novoter
  Teofarma, Spain



• Pelisani
  Derma 3, Peru



• Ruful
  Hisamitsu, Japan



• Simaron
  Toko Pharmaceutical, Japan



• Solunim
  Towa Yakuhin, Japan



• Tiamol
  Taro, Canada



• Topsym
  Grünenthal, Switzerland; Grünenthal, Germany; Grünenthal, Oman; Grünenthal, Peru; Tanabe, Taiwan; Tanabe Mitsubishi, Japan



• Topsyn
  Syntex, Mexico; Teofarma, Italy



• Vanos
  Medicis, United States

International Drug Name Search

Glossary

BAN	British Approved Name
DCF	Dénomination Commune Française
DCIT	Denominazione Comune Italiana
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Ketoconazol Best

Ketoconazol Best may be available in the countries listed below.

Ingredient matches for Ketoconazol Best

Ketoconazole

Ketoconazole is reported as an ingredient of Ketoconazol Best in the following countries:

• Colombia

International Drug Name Search

Adco-Nebrafen

Adco-Nebrafen may be available in the countries listed below.

Ingredient matches for Adco-Nebrafen

Fenoterol

Fenoterol hydrobromide (a derivative of Fenoterol) is reported as an ingredient of Adco-Nebrafen in the following countries:

• South Africa

Ipratropium

Ipratropium Bromide is reported as an ingredient of Adco-Nebrafen in the following countries:

• South Africa

International Drug Name Search

Héparine Sodique Panpharma

Héparine Sodique Panpharma may be available in the countries listed below.

Ingredient matches for Héparine Sodique Panpharma

Heparin

Heparin sodium salt (a derivative of Heparin) is reported as an ingredient of Héparine Sodique Panpharma in the following countries:

• France

International Drug Name Search

Growtropin

Growtropin may be available in the countries listed below.

Ingredient matches for Growtropin

Somatropine

Somatropine is reported as an ingredient of Growtropin in the following countries:

• Peru

International Drug Name Search

Rebilex-ISR

Rebilex-ISR may be available in the countries listed below.

Ingredient matches for Rebilex-ISR

Itopride

Itopride is reported as an ingredient of Rebilex-ISR in the following countries:

• India

Rabeprazole

Rabeprazole is reported as an ingredient of Rebilex-ISR in the following countries:

• India

International Drug Name Search

Chewable Vitamin C

Chewable Vitamin C may be available in the countries listed below.

Ingredient matches for Chewable Vitamin C

Ascorbic Acid

Ascorbic Acid is reported as an ingredient of Chewable Vitamin C in the following countries:

• Israel

International Drug Name Search

Migranil Inga

Migranil Inga may be available in the countries listed below.

Ingredient matches for Migranil Inga

Ergotamine

Ergotamine tartrate (a derivative of Ergotamine) is reported as an ingredient of Migranil Inga in the following countries:

• Sri Lanka

International Drug Name Search

Gabapentina Normon

Gabapentina Normon may be available in the countries listed below.

Ingredient matches for Gabapentina Normon

Gabapentin

Gabapentin is reported as an ingredient of Gabapentina Normon in the following countries:

• Spain

International Drug Name Search

Fluvastatine Sandoz

Fluvastatine Sandoz may be available in the countries listed below.

Ingredient matches for Fluvastatine Sandoz

Fluvastatin

Fluvastatin sodium salt (a derivative of Fluvastatin) is reported as an ingredient of Fluvastatine Sandoz in the following countries:

• France

International Drug Name Search

Cefazolina K24

Cefazolina K24 may be available in the countries listed below.

Ingredient matches for Cefazolina K24

Cefazolin

Cefazolin sodium salt (a derivative of Cefazolin) is reported as an ingredient of Cefazolina K24 in the following countries:

• Italy

International Drug Name Search

Kulax

Kulax may be available in the countries listed below.

Ingredient matches for Kulax

Lactulose

Lactulose is reported as an ingredient of Kulax in the following countries:

• Oman

International Drug Name Search

Enap

Enap may be available in the countries listed below.

Ingredient matches for Enap

Enalapril

Enalapril is reported as an ingredient of Enap in the following countries:

• Bosnia & Herzegowina


• Romania

Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Enap in the following countries:

• Bulgaria


• Croatia (Hrvatska)


• Czech Republic


• Estonia


• Georgia


• Hungary


• Ireland


• Latvia


• Lithuania


• Poland


• Romania


• Russian Federation


• Serbia


• Singapore


• Slovakia


• Slovenia


• South Africa

Enalaprilat

Enalaprilat dihydrate (a derivative of Enalaprilat) is reported as an ingredient of Enap in the following countries:

• Croatia (Hrvatska)


• Czech Republic


• Estonia


• Hungary


• Slovakia

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Enap in the following countries:

• Bulgaria


• Croatia (Hrvatska)


• Hungary


• Slovakia


• Slovenia

International Drug Name Search

Aftadur

Aftadur may be available in the countries listed below.

Ingredient matches for Aftadur

Povidone

Povidone is reported as an ingredient of Aftadur in the following countries:

• Turkey

International Drug Name Search

Löscalcon

Löscalcon may be available in the countries listed below.

Ingredient matches for Löscalcon

Calcium Carbonate

Calcium Carbonate is reported as an ingredient of Löscalcon in the following countries:

• Germany

International Drug Name Search

Lanexat

Lanexat may be available in the countries listed below.

Ingredient matches for Lanexat

Flumazenil

Flumazenil is reported as an ingredient of Lanexat in the following countries:

• Argentina


• Brazil


• Chile


• Colombia


• Ecuador


• Finland


• Iceland


• Mexico


• Peru


• Sweden


• Venezuela

International Drug Name Search

Tauredon

Tauredon may be available in the countries listed below.

Ingredient matches for Tauredon

Sodium Aurothiomalate

Sodium Aurothiomalate is reported as an ingredient of Tauredon in the following countries:

• Czech Republic


• Germany


• Netherlands


• Portugal


• Romania


• Serbia


• Slovakia


• Switzerland

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Hy-Po-Tone

Hy-Po-Tone may be available in the countries listed below.

Ingredient matches for Hy-Po-Tone

Methyldopa

Methyldopa is reported as an ingredient of Hy-Po-Tone in the following countries:

• Ethiopia


• South Africa

International Drug Name Search

Metamizol Hexal

Metamizol Hexal may be available in the countries listed below.

Ingredient matches for Metamizol Hexal

Metamizole

Metamizole sodium monohydrate (a derivative of Metamizole) is reported as an ingredient of Metamizol Hexal in the following countries:

• Germany

International Drug Name Search

Xylometazolin

Xylometazolin may be available in the countries listed below.

Ingredient matches for Xylometazolin

Xylometazoline

Xylometazoline hydrochloride (a derivative of Xylometazoline) is reported as an ingredient of Xylometazolin in the following countries:

• Georgia


• Germany


• Lithuania


• Poland

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Pilactone

Pilactone may be available in the countries listed below.

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Spironolactone

Spironolactone is reported as an ingredient of Pilactone in the following countries:

• Bangladesh

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Cyclovent

Cyclovent may be available in the countries listed below.

Ingredient matches for Cyclovent

Ipratropium

Ipratropium Bromide is reported as an ingredient of Cyclovent in the following countries:

• Latvia

International Drug Name Search

Congex

Congex may be available in the countries listed below.

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Naproxen

Naproxen is reported as an ingredient of Congex in the following countries:

• Argentina

International Drug Name Search

Ridwind

Ridwind may be available in the countries listed below.

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Simeticone

Simeticone is reported as an ingredient of Ridwind in the following countries:

• Singapore

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Tilidin comp. AWD

Tilidin comp. AWD may be available in the countries listed below.

Ingredient matches for Tilidin comp. AWD

Naloxone

Naloxone hydrochloride (a derivative of Naloxone) is reported as an ingredient of Tilidin comp. AWD in the following countries:

• Germany

Tilidine

Tilidine hydrochloride hemihydrate (a derivative of Tilidine) is reported as an ingredient of Tilidin comp. AWD in the following countries:

• Germany

International Drug Name Search

Fluconazol Sala

Fluconazol Sala may be available in the countries listed below.

Ingredient matches for Fluconazol Sala

Fluconazole

Fluconazole is reported as an ingredient of Fluconazol Sala in the following countries:

• Spain

International Drug Name Search

Polibar ABC

Polibar ABC may be available in the countries listed below.

Ingredient matches for Polibar ABC

Barium Sulfate

Barium Sulfate is reported as an ingredient of Polibar ABC in the following countries:

• Poland

International Drug Name Search

Liqua Cortril

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Liqua Cortril

Hydrocortisone

Hydrocortisone is reported as an ingredient of Liqua Cortril in the following countries:

• United States

Oxytetracycline

Oxytetracycline hydrochloride (a derivative of Oxytetracycline) is reported as an ingredient of Liqua Cortril in the following countries:

• United States

International Drug Name Search

Finasteride AccordHealthcare

Finasteride AccordHealthcare may be available in the countries listed below.

Ingredient matches for Finasteride AccordHealthcare

Finasteride

Finasteride is reported as an ingredient of Finasteride AccordHealthcare in the following countries:

• Netherlands

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Ranitidine 150mg Tablets (Goldshield plc)

1. Name Of The Medicinal Product

Ranitidine 150mg Tablets

2. Qualitative And Quantitative Composition

Each tablet contains Ranitidine hydrochloride Ph.Eur. equivalent to Ranitidine 150 mg

3. Pharmaceutical Form

Circular, biconvex, white to yellowish film-coated biconvex circular. Diameter. 10mm.

4. Clinical Particulars

4.1 Therapeutic Indications

Adults

Goldshield Ranitidine tablets are indicated in the treatment of ulcers of the duodenum and of benign gastric ulcers, including those associated with use of non-steroidal anti-inflammatory agents (NSAID's) and/or prevention of NSAID induced duodenal ulcers.

Goldshield Ranitidine tablets may also be used in conditions where reduction of gastric secretion and acid output may be beneficial, such as: prophylaxis of gastrointestinal haemorrhage arising from stress ulceration in seriously ill patients; prophylaxis of recurring haemorrhage associated with bleeding peptic ulcers; before general anaesthesia in patients considered to be at risk of acid aspiration (Mendelson's syndrome) for example in obstetric patients during labour.

Other indications include the treatment of Zollinger-Ellison syndrome, gastro-oesophageal reflux disease (including the long-term management of healed oesophagitis) and post-operative ulcer. Patients with chronic episodic dyspepsia, characterised by pain (epigastric or retrosternal) which disturbs sleep or is related to meals but is not associated with the preceding conditions may also benefit from treatment with Goldshield Ranitidine.

Children (3 to 18 years)

- Short term treatment of peptic ulcer

- Treatment of gastro-oesophageal reflux, including reflux oesophagitis and symptomatic relief of gastro-oesophageal reflux disease.

4.2 Posology And Method Of Administration

Adults and the elderly:

Treatment of ulcers

The normal starting dose is Goldshield Ranitidine 150 mg twice daily, morning and evening. Absorption is not affected by the presence of food.

Patients with duodenal ulceration. gastric ulceration or gastro-oesophageal reflux disease may be treated with a single dose of 300 mg at bedtime. In duodenal ulcer it has been reported that use of 300 mg twice daily for 4 weeks results in healing rates which are higher than those at 4 weeks with ranitidine 150mg twice daily or 300 mg nocte. without an associated increase in the incidence of adverse reactions.

In most cases of duodenal ulcer, benign gastric ulcer and post-operative ulcer, healing occurs in four weeks. A further four week course of treatment may be necessary in those patients whose ulcers have not fully healed after the initial course of therapy; healing normally takes place following the second course of treatment.

NSAID associated ulcers

In ulcers following NSAID therapy or associated with continued NSAID's, eight weeks' treatment may be necessary to induce healing.

For the prevention of NSAID associated duodenal ulcers, Goldshield Ranitidine 150mg twice daily may be given with NSAID therapy.

Maintenance treatment of ulcers

Maintenance treatment at a reduced dosage of 150 mg at bedtime is recommended for patients who have responded to short-term therapy, particularly those with a history of recurrent ulcer.

Oesophageal Reflux Disease

In the management of oesophageal reflux disease, the recommended course of treatment is either 150 mg twice daily or 300mg at bedtime for up to 8 or 12 weeks.

In patients with moderate to severe gastro-oesophagitis, the dosage of ranitidine may be increased to 150 mg four times daily for up to twelve weeks. The increased dose has not been associated with an increased incidence of adverse reactions.

The recommended adult oral dose is 150 mg twice daily for the long-term treatment of healed oesophagitis. Long-term treatment is not indicated in the management of patients with unhealed oesophagitis.

Mendelson's Syndrome

Goldshield Ranitidine tablets 150 mg can be given orally 2 hours before induction of general anaesthesia, and if possible, an additional dose of 150 mg the previous evening, in patients regarded to be at risk of acid aspiration syndrome.

At onset of labour, an oral dose of 150 mg Goldshield Ranitidine may be given to obstetric patients followed by a further 150 mg every six hours. Since gastric emptying and drug absorption are delayed during labour, it is recommended that any patient requiring emergency general anaesthesia should also be given a non-particulate antacid (e.g. sodium citrate) prior to induction of anaesthesia. The usual precautions to avoid acid aspiration should also be taken.

Zollinger-Ellison syndrome

In patients with Zollinger-Ellison syndrome, the recommended starting dose is 150 mg three times daily, which may be increased as necessary. Doses increasing to 6 g per day have been used in patients with this syndrome and it has been reported that these doses have been well tolerated.

Chronic episodic dyspepsia

The recommended course of treatment in such cases is 150 mg twice daily for up to six weeks. Further investigations should be carried out in non-responding patients.

Children

Children from 3 to 11 years and over 30 kg of weight

See Section 5.2 Pharmacokinetic Properties - Special Patient Populations.

Peptic Ulcer Acute Treatment

The recommended oral dose for the treatment of peptic ulcer in children is 4 mg/kg/day to 8 mg/kg/day administered as two divided doses to a maximum of 300 mg ranitidine per day for a duration of 4 weeks. For those patients with incomplete healing, another 4 weeks of therapy is indicated, as healing usually occurs after eight weeks of treatment.

Gastro-Oesophageal Reflux

The recommended oral dose for the treatment of gastro-oesophageal reflux in children is 5 mg/kg/day to 10 mg/kg/day administered as two divided doses in a maximum dose of 600 mg (the maximum dose is likely to apply to heavier children or adolescents with severe symptoms).

Safety and efficacy in new-born patients has not been established.

4.3 Contraindications

Goldshield Ranitidine tablets are contra-indicated in patients hypersensitive to any ingredient of the preparation.

4.4 Special Warnings And Precautions For Use

Treatment with H₂ - antagonists such as ranitidine may mask symptoms associated with carcinoma of the stomach. In order to avoid delays in diagnosis of this condition, in patients of middle age and over with new or recently changed dyspeptic symptoms, or where Gastric ulcer is suspected, the possibility of malignancy should be excluded before therapy with Goldshield Ranitidine Tablets commences.

A large epidemiological study showed an increased risk of developing community acquired pneumonia in current users of H2 receptor antagonists versus those who had stopped treatment, with an observed adjusted relative risk increase of 1.82 (95% CI, 1.26 -2.64).This increased risk was mainly observed in patients with pulmonary diseases, diabetes, heart failure and in immunocompromised patients.

Current evidence shows that Ranitidine only protects against NSAID associated ulceration in the duodenum, not in the stomach. Regular supervision of all patients, but especially the elderly, who are taking NSAID's concomitantly with Ranitidine is recommended.

Clinical reports of acute intermittent porphyria associated with Ranitidine administration have been rare and inconclusive. However, Ranitidine should be avoided in patients with a history of this condition.

As Ranitidine is excreted via the kidney, plasma levels of the drug are increased in patients with severe renal impairment. It is therefore recommended that a reduced starting dose of Goldshield Ranitidine is utilised in such patients i.e. 150 mg at night for 4 to 8 weeks. The same dose should be used for maintenance treatment if deemed necessary. If an ulcer has not healed after treatment the standard dosage regimen of 150 mg twice daily may be commenced, followed, if necessary, by maintenance treatment of 150mg at night.

Use in renal transplants

Ranitidine has been used successfully in patients with renal transplants.

Use in elderly patients

Similar rates of healing of ulcers and adverse reaction profiles have been observed in patients aged 65 and over compared to younger patients.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Ranitidine has the potential to affect the absorption, metabolism or renal excretion of other drugs. The altered pharmacokinetics may necessitate dosage adjustment of the affected drug or discontinuation of treatment

Interactions occur by several mechanisms including:

1) Inhibition of cytochrome P450-linked mixed function oxygenase system: Ranitidine at usual therapeutic doses does not potentiate the actions of drugs which are inactivated by this enzyme system such as diazepam, lidocaine, phenytoin, propanolol and theophylline.

There have been reports of altered prothrombin time with coumarin anticoagulants (e.g. warfarin). Due to the narrow therapeutic index, close monitoring of increased or decreased prothrombin time is recommended during concurrent treatment with ranitidine.

2) Competition for renal tubular secretion:

Since ranitidine is partially eliminated by the cationic system, it may affect the clearance of other drugs eliminated by this route. High doses of ranitidine (e.g. such as those used in the treatment of Zollinger-Ellison syndrome) may reduce the excretion of procainamide and N-acetylprocainamide resulting in increased plasma level of these drugs.

3) Alteration of gastric pH:

The bioavailability of certain drugs may be affected. This can result in either an increase in absorption (e.g. triazolam, midazolam, glipizide) or a decrease in absorption (e.g. ketoconazole, atazanavir, delaviridine, gefitnib).

There is no evidence of an interaction between ranitidine and metronidazole or amoxycillin.

4.6 Pregnancy And Lactation

Like other drugs, Goldshield Ranitidine tablets should only be used during pregnancy and nursing if considered essential by the physician. Ranitidine is excreted in human breast milk.

Ranitidine crosses the placenta but therapeutic doses administered to obstetric patients in labour or undergoing caesarean section at the recommended dosage (see sections 4.1 & 4.2) have been without any adverse effect on labour, delivery or subsequent neonatal progress.

4.7 Effects On Ability To Drive And Use Machines

Ranitidine may cause dizziness and the patient should be warned not to drive or to operate machinery if affected.

4.8 Undesirable Effects

The following convention has been utilised for the classification of undesirable effects: very common (

Blood & Lymphatic System Disorders

Unknown: Blood count changes (leucopenia, thrombocytopenia). These are usually reversible. Agranulocytosis or pancytopenia, sometimes with marrow hypoplasia or marrow aplasia.

Immune System Disorders

Uncommon: Hypersensitivity reactions (urticaria, angioneurotic oedema, fever, bronchospasm, hypotension and chest pain).

Unknown: Anaphylactic shock

These events have been reported after a single dose.

Psychiatric Disorders

Very Rare: Depression.

Unknown: Reversible mental confusion, depression and hallucinations.

These have been reported predominantly in severely ill and elderly patients.

Nervous System Disorders

Common: Headache (sometimes severe) and dizziness

Unknown: Reversible involuntary movement disorders.

Eye Disorders

Uncommon: Reversible blurred vision.

There have been reports of blurred vision, which is suggestive of a change in accommodation.

Cardiac Disorders

Unknown: As with other H₂ receptor antagonists bradycardia and A-V Block.

Vascular Disorders

Unknown: Vasculitis.

Gastrointestinal Disorders

Common: Diarrhoea

Unknown: Acute pancreatitis.

Hepatobiliary Disorders

Very Rare: Transient and reversible changes in liver function tests.

Unknown: Hepatitis (hepatocellular, hepatocanalicular or mixed) with or without jaundice, these were usually reversible.

Skin and Subcutaneous Tissue Disorders

Uncommon: Skin Rash.

Unknown: Erythema multiforme, alopecia.

Musculoskeletal and Connective Tissue Disorders

Unknown: Musculoskeletal symptoms such as arthralgia and myalgia.

Renal and Urinary Disorders

Unknown: Acute interstitial nephritis.

Reproductive System and Breast Disorders

Unknown: Reversible impotence. Breast symptoms and breast conditions (such as gynaecomastia and galactorrhea).

The safety of ranitidine has been assessed in children aged 0 to 16 years with acid-related disease and was generally well tolerated with an adverse event profile resembling that in adults. There are limited long term safety data available, in particular regarding growth and development.

4.9 Overdose

No specific antidote is available. However, no particular problems are expected following overdosage due to the specificity of action of ranitidine. Symptomatic and supportive therapy should be given as appropriate. Ranitidine may be removed from the plasma by haemodialysis.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Ranitidine is a specific, rapidly acting histamine H₂ -antagonist. It inhibits both basal and stimulated secretion of gastric acid, thereby reducing both the volume and the acid and pepsin content of gastric secretions. Ranitidine has a relatively long duration of action. A single dose effectively suppresses gastric acid secretion for up to twelve hours.

5.2 Pharmacokinetic Properties

Absorption of ranitidine after oral administration is rapid and peak plasma concentrations are usually achieved 2-3 hours after administration. Absorption is not significantly impaired by food or antacids. Oral bioavailability is approximately 50%.

Ranitidine is approximately 15% protein bound.

Metabolism of ranitidine is not extensive, and elimination of the drug is primarily by tubular secretion. The elimination half-life of ranitidine is 2-3 hours. In balance studies with 150 mg 3H-ranitidine 60-70% of an oral dose was excreted in urine and 26% in faeces. 35% of the oral dose was eliminated unchanged in the urine in the first 24 hours after dosing. Approximately 6% of the dose is excreted as the N-oxide, 2% as the S-oxide, 2% as desmethyl ranitidine and 1-2% as the furoic acid analogue.

Special Patient Populations

Children (3 years and above)

Limited pharmacokinetic data have shown that there are no significant differences in half-life (range for children 3 years and above: 1.7 - 2.2 h) and plasma clearance (range for children 3 years and above: 9 - 22 ml/min/kg) between children and healthy adults receiving oral ranitidine when correction is made for body weight.

5.3 Preclinical Safety Data

There was no indication of tumourigenic or carcinogenic effects in life-span studies in mice and rats at dosages up to 2,000 mg/kg per day.

Ranitidine was not mutagenic in standard bacterial tests (Salmonella, Escherichia coli) for mutagenicity at concentrations up to the maximum recommended for these assays. In a dominant lethal assay, a single oral dose of 1,000 mg/kg to male rats was without effect on the outcome of two matings per week for the next nine weeks.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Croscarmellose sodium Ph.Eur

Magnesium stearate Ph.Eur.

Microcrystalline cellulose Ph.Eur.

Hydroxypropylmethylcellulose Ph.Eur.

Titanium dioxide Ph.Eur.

Talc Ph.Eur.

Polyethylene glycol 6000 Ph Eur

Polymethylmethacrylic acid copolymer (Eudragit E)

6.2 Incompatibilities

None known.

6.3 Shelf Life

2 years (unopened).

6.4 Special Precautions For Storage

Store below 25°C in a dry place.

6.5 Nature And Contents Of Container

Carton of 60 tablets, packed in A1/A1 blisters.

6.6 Special Precautions For Disposal And Other Handling

No special requirements.

ADMINISTRATIVE DATA

7. Marketing Authorisation Holder

Goldshield Pharmaceuticals Ltd.

NLA Tower, 12-16 Addiscombe Road

Croydon, CR0 0XT

United Kingdom.

8. Marketing Authorisation Number(S)

PL 12762/0011

9. Date Of First Authorisation/Renewal Of The Authorisation

27 October 1997

10. Date Of Revision Of The Text

01/03/2010

Theralene

Theralene may be available in the countries listed below.

Ingredient matches for Theralene

Alimemazine

Alimemazine is reported as an ingredient of Theralene in the following countries:

• Luxembourg

Alimemazine tartrate (a derivative of Alimemazine) is reported as an ingredient of Theralene in the following countries:

• Belgium


• Vietnam

International Drug Name Search

Atenolol Adico

Atenolol Adico may be available in the countries listed below.

Ingredient matches for Atenolol Adico

Atenolol

Atenolol is reported as an ingredient of Atenolol Adico in the following countries:

• Switzerland

International Drug Name Search

Anticholium

Anticholium may be available in the countries listed below.

Ingredient matches for Anticholium

Physostigmine

Physostigmine salicylate (a derivative of Physostigmine) is reported as an ingredient of Anticholium in the following countries:

• Austria


• Germany

International Drug Name Search

Topistin

Topistin may be available in the countries listed below.

Ingredient matches for Topistin

Ciprofloxacin

Ciprofloxacin hydrochloride (a derivative of Ciprofloxacin) is reported as an ingredient of Topistin in the following countries:

• Greece

International Drug Name Search

Budésonide

Budésonide may be available in the countries listed below.

Ingredient matches for Budésonide

Budesonide

Budésonide (DCF) is known as Budesonide in the US.

International Drug Name Search

Glossary

DCF	Dénomination Commune Française

Click for further information on drug naming conventions and International Nonproprietary Names.

Prazolex

Prazolex may be available in the countries listed below.

Ingredient matches for Prazolex

Alprazolam

Alprazolam is reported as an ingredient of Prazolex in the following countries:

• Romania

International Drug Name Search

Pharmaniaga Propranolol

Pharmaniaga Propranolol may be available in the countries listed below.

Ingredient matches for Pharmaniaga Propranolol

Propranolol

Propranolol hydrochloride (a derivative of Propranolol) is reported as an ingredient of Pharmaniaga Propranolol in the following countries:

• Malaysia

International Drug Name Search

Prothicid

Prothicid may be available in the countries listed below.

Ingredient matches for Prothicid

Protionamide

Protionamide is reported as an ingredient of Prothicid in the following countries:

• India

International Drug Name Search

Catanac

Catanac may be available in the countries listed below.

Ingredient matches for Catanac

Diclofenac

Diclofenac potassium salt (a derivative of Diclofenac) is reported as an ingredient of Catanac in the following countries:

• Indonesia

International Drug Name Search

Betasid

Betasid may be available in the countries listed below.

Ingredient matches for Betasid

Betamethasone

Betamethasone 17α-valerate (a derivative of Betamethasone) is reported as an ingredient of Betasid in the following countries:

• Greece

Fusidic Acid

Fusidic Acid is reported as an ingredient of Betasid in the following countries:

• Greece

International Drug Name Search

Magnesioboi

Magnesioboi may be available in the countries listed below.

Ingredient matches for Magnesioboi

Magnesium Lactate

Magnesium Lactate is reported as an ingredient of Magnesioboi in the following countries:

• Spain

International Drug Name Search

Bisolvon Ampicilina

Bisolvon Ampicilina may be available in the countries listed below.

Ingredient matches for Bisolvon Ampicilina

Ampicillin

Ampicillin is reported as an ingredient of Bisolvon Ampicilina in the following countries:

• Peru

Bromhexine

Bromhexine is reported as an ingredient of Bisolvon Ampicilina in the following countries:

• Peru

International Drug Name Search

Carnaculin

Carnaculin may be available in the countries listed below.

Ingredient matches for Carnaculin

Kallidinogenase

Kallidinogenase is reported as an ingredient of Carnaculin in the following countries:

• Japan

International Drug Name Search

Propicillin

Scheme

Prop.INN

ATC (Anatomical Therapeutic Chemical Classification)

J01CE03

CAS registry number (Chemical Abstracts Service)

0000551-27-9

Chemical Formula

C18-H22-N2-O5-S

Molecular Weight

378

Therapeutic Category

Antibacterial: Penicillin, penicillinase-sensitive

Chemical Name

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenoxybutyl)amino]-, [2S-(2α,5α,6ß)]-

Foreign Names

• Propicillinum (Latin)
• Propicillin (German)
• Propicilline (French)
• Propicilina (Spanish)

Generic Names

• Propicillin (OS: BAN)
• Propicillina (OS: DCIT)
• Propicilline (OS: DCF)
• (1-Phenoxypropyl)penicillin (IS: WHO)
• 6-(α-Phenoxybutyramido)penicillansäure (IS: ASK)
• Bayer 5395 (IS: Bayer)
• PA 248 (IS)
• Propicillin Potassium (OS: BANM, JAN)
• 6-(α-Phenoxybutyramido)penicillansäure, Kaliumsalz (IS: ASK)
• Propicillinum kalicum (IS)
• Propicillin Potassium (PH: BP 1973)
• Propicillinum Kalicum (PH: Ph. Int. 2)

Brand Name

• Baycillin
  Bayer, Germany

International Drug Name Search

Glossary

BAN	British Approved Name
BANM	British Approved Name (Modified)
DCF	Dénomination Commune Française
DCIT	Denominazione Comune Italiana
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Prop.INN	Proposed International Nonproprietary Name (World Health Organization)
WHO	World Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

Bupivacaina Hiperbarica

Bupivacaina Hiperbarica may be available in the countries listed below.

Ingredient matches for Bupivacaina Hiperbarica

Bupivacaine

Bupivacaine hydrochloride (a derivative of Bupivacaine) is reported as an ingredient of Bupivacaina Hiperbarica in the following countries:

• Chile

International Drug Name Search

Mefoln

Mefoln may be available in the countries listed below.

Ingredient matches for Mefoln

Mefloquine

Mefloquine is reported as an ingredient of Mefoln in the following countries:

• Bangladesh

International Drug Name Search

Amiorel

Amiorel may be available in the countries listed below.

Ingredient matches for Amiorel

Bromhexine

Bromhexine hydrochloride (a derivative of Bromhexine) is reported as an ingredient of Amiorel in the following countries:

• Argentina

International Drug Name Search

L-Thyrox Hexal

L-Thyrox Hexal may be available in the countries listed below.

Ingredient matches for L-Thyrox Hexal

Levothyroxine

Levothyroxine sodium salt (a derivative of Levothyroxine) is reported as an ingredient of L-Thyrox Hexal in the following countries:

• Estonia


• Germany

International Drug Name Search

Metracop

Metracop may be available in the countries listed below.

Ingredient matches for Metracop

Tramadol

Tramadol hydrochloride (a derivative of Tramadol) is reported as an ingredient of Metracop in the following countries:

• Denmark

International Drug Name Search

Elmetin

Elmetin may be available in the countries listed below.

Ingredient matches for Elmetin

Mebendazole

Mebendazole is reported as an ingredient of Elmetin in the following countries:

• Bahrain


• Oman


• Sri Lanka


• Taiwan

International Drug Name Search

Ranitidina ABC

Ranitidina ABC may be available in the countries listed below.

Ingredient matches for Ranitidina ABC

Ranitidine

Ranitidine hydrochloride (a derivative of Ranitidine) is reported as an ingredient of Ranitidina ABC in the following countries:

• Italy

International Drug Name Search

Calcium Folinate

UK matches:

• Calcium Folinate 10mg/ml Injection (Hospira UK Ltd)
• Calcium Folinate 15mg Tablets (Hospira UK Ltd)
• Calcium Folinate 3mg/ml Injection (Hospira UK Ltd)
• Calcium Folinate 10 mg/mL Injection (SPC)
• Calcium Folinate 15mg Tablets (Hospira UK Ltd) (SPC)
• Calcium Folinate 3 mg/mL Injection (SPC)
• Calcium Folinate 7.5 mg/mL Injection (SPC)

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

V03AF03

CAS registry number (Chemical Abstracts Service)

0001492-18-8

Chemical Formula

C20-H21-Ca-N7-O7

Molecular Weight

511

Therapeutic Categories

Antidote against folic acid antagonists

Detoxifying agent for antineoplastic treatment

Chemical Name

Calcium N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamate (WHO)

Foreign Names

• Calcii folinas (Latin)
• Calcium folinat (German)
• Folinate de calcium (French)
• Folinato cálcico (Spanish)

Generic Names

• Calcium Folinate (OS: JAN, BAN)
• Folinato di calcio (OS: DCIT)
• (+)-L-Folinic acid, calcium salt (IS)
• Calcifolin (IS)
• Calcio folinato (IS)
• Calcium citrovorum factor (IS)
• Calfonat (IS)
• Folinat-SF Calcium (IS)
• Folinic acid calcium salt (IS)
• Leucovorin Calcium (IS)
• Calcii folinas (PH: Ph. Int. 4, Ph. Eur. 5)
• Calcium Folinate (PH: BP 2010, Ph. Eur. 5, Ph. Int. 4, JP XV)
• Leucovorin Calcium (PH: USP 32)
• Folinsäure, Calciumsalz-5-Wasser (IS)
• NSC 3590 (IS)

Brand Names

• Antrex
  Atafarm, Turkey; Orion, Finland; Orion, Taiwan



• Asovorin
  Raffo, Argentina



• Axifolin
  Apocare, Germany



• Bendafolin
  Bendalis, Germany



• Buateron
  Farmedia, Greece



• Calcifolin
  Kleva, Greece



• Calcium Folinat Ebewe
  Ebewe, Myanmar; Würth, Croatia (Hrvatska)



• Calcium Folinat
  Ebewe, Georgia; Ebewe, Romania



• Calcium Folinate Ebewe
  InterPharma, New Zealand; Pharmanel, Greece



• Calcium Folinate Gerolymatos
  png Gerolymatos, Greece



• Calcium Folinate Hospira
  Hospira, Greece



• Calcium Folinate
  Hospira, United Kingdom; Hospira, Malta



• Calcium Leucovorin
  Mayne, Ireland; Orna, Turkey; Wyeth, India; Wyeth, Oman



• Calciumfolin
  Kleva, Greece



• Calciumfolinat APP
  Abraxis, Switzerland



• Calciumfolinat biosyn
  Biosyn, Germany



• Calciumfolinat Ebewe
  Ebewe, Austria; Ebewe, Bulgaria; Ebewe, Estonia; Ebewe, Hong Kong; Ebewe, Serbia; Ebewe, Vietnam; Sandoz, Switzerland



• Calciumfolinat Hospira
  Hospira, Germany; Hospira, Finland; Hospira Nordic, Sweden



• Calciumfolinat Mayne
  Hospira, Norway; Mayne, Denmark



• Calciumfolinat Meda
  Meda, Denmark



• Calciumfolinat medinal
  Medinal, Germany



• Calciumfolinat Medipolis
  Medipolis Produktion, Germany



• Calciumfolinat Medis
  Actavis, Switzerland



• Calciumfolinat onkovis
  Onkovis, Germany



• Calciumfolinat Stada
  Stada, Austria



• Calciumfolinat Vipharm
  Vipharm, Germany



• Calciumfolinat
  Meda, Norway



• Calciumfolinate Teva
  Teva, Sweden



• Calciumfolinat-Ebewe
  Ebewe, Hungary; Ebewe, Russian Federation; Ebewe, Tunisia



• Calcivoran
  Vocate, Greece



• Citofolin
  Bracco, Italy



• Claro
  ITF, Greece



• Cromatonbic Folinico
  Menarini, Spain



• Dabur Leucovorin
  Dabur, Myanmar; Dabur, Philippines



• Dalisol
  Lemery, Mexico; Lemery, Peru



• Degalin
  Riemser, Germany



• Durofolin
  Biotrends, Greece



• Ebefolinat Ebewe
  OncoCorp, Germany



• Eparmefolin (Calcium Folinate and Cyanocobalamin)
  Bracco, Italy



• Estroquin
  Richmond, Argentina; Richmond, Peru



• Etamolin
  AC Farma, Peru



• Fedolen
  Viofar, Greece



• Ferritin Complex (Calcium Folinate and Ferrous Gluconate complex)
  ABC, Italy



• Folaren
  Istituto Chim. Internazionale, Italy



• Folcasin
  Sindan, Romania



• Folical
  Proel, Greece



• Foli-cell
  Stada, Austria



• Folidan
  Merck Genericos, Spain



• Folidar
  Italfarmaco, Italy



• Foliment
  Sanopharm, Greece



• Folinacid
  Anesths Karamthsos, Greece



• Folinate de calcium Aguettant
  Aguettant, France; Aguettant, Tunisia



• Folinate de calcium Dakota Pharm
  Dakota, Tunisia; Sanofi-Aventis, France



• Folinate de calcium Sandoz
  Sandoz, France



• Folinate de calcium Winthrop
  Sanofi-Aventis, France



• Folinate EG
  Eurogenerics, Luxembourg



• Folinato Calcico Ferrer Farma
  Ferrer, Spain



• Folinato Calcico G.E.S.
  Ges Genericos, Spain



• Folinato Calcico Genfarma
  Genfarma, Spain



• Folinato Calcico Servycal
  Servycal, Peru



• Folinato Calcico Teva
  Teva, Spain



• Folinato Calcio Deutsche Pharma
  Deutsche Pharma, Peru



• Folinato de Calcio Vitalis
  Vitalis, Peru



• Folinato de Calcio World Pharma
  World Pharma, Peru



• Folinato
  Faran Laboratories, Greece



• Folinfabra
  Fabra, Argentina



• Folinsäure-Actavis
  Actavis, Germany



• Folisachs
  Oncosachs, Germany



• Folmigor
  Chrispa, Greece



• Haemato-folin
  Haemato, Germany



• Kalcij-folinat Pliva
  Pliva, Bosnia & Herzegowina; Pliva, Croatia (Hrvatska)



• Kalsiumfolinat
  Pfizer, Norway



• Kalsiyum Folinat Ebewe
  Liba, Turkey



• Lederfolin Oral
  Lederle, Spain



• Lederfolin
  Wyeth, Spain; Wyeth, Ireland



• Lederfoline
  Teofarma, Portugal; Wyeth, France



• Lederle Leucovorin Calcium
  Wyeth, Canada



• Ledervorin Calcium
  AHP, Luxembourg; Wyeth, Luxembourg



• Leucocalcin
  LKM, Argentina



• Leuconolver
  Nolver, Venezuela



• Leucovorin Abic
  Abic, Israel



• Leucovorin Ca
  Lachema, Romania; Lachema, Serbia; Pliva, Poland; Pliva, Serbia



• Leucovorin Calcium DBL
  DBL/Faulding, Bangladesh; Hospira, Indonesia; Hospira, Singapore; Mayne, Hong Kong; Mayne, Malaysia; Tempo Scan Pacific, Indonesia



• Leucovorin Calcium Farmos
  Orion, Switzerland



• Leucovorin Calcium Pfizer
  Pfizer, Singapore



• Leucovorin Calcium
  Bedford, United States; CorePharma, United States; Cyanamid, Oman; Hospira, Australia; Hospira, Canada; Hospira, New Zealand; Pfizer, Serbia; Roxane, United States; Sandoz, United States; Teva USA, United States; UDL, United States; Wyeth, Taiwan; Xanodyne, United States; PfizerPerth, Australia



• Leucovorin Calcium-Mayne
  Hospira, Luxembourg



• Leucovorin Kalbe
  Kalbe, Indonesia



• Leucovorin Lachema
  Pliva, Russian Federation



• Leucovorin Teva
  Teva, Czech Republic; Teva, Lithuania; Teva, Latvia



• Leucovorin
  Teva, Israel; Wyeth, Greece; Wyeth, Slovenia; Wyeth KK, Japan



• Leucovorina Cal
  Pfizer, Peru



• Leucovorina Calcica Filaxis
  Filaxis, Argentina



• Leucovorina Calcica Raffo
  Raffo, Argentina



• Leucovorina Calcica Varifarma
  Varifarma, Argentina



• Leucovorina Calcica
  Pfizer, Ecuador; Pfizer, Venezuela; Teva, Argentina



• Leucovorina Delta Farma
  Delta Farma, Argentina



• Leucovorina Servycal
  Servycal, Argentina



• Leucovorina
  Pfizer, Colombia



• Leucovorine Teva
  Pharmachemie, Romania



• Leucovorin-Teva
  Med, Turkey; Teva, Hungary; Teva Pharma, Switzerland



• Leukovorin Calcium
  Pfizer, Serbia



• Lizocalcio
  S.J.A., Greece



• Medifolin
  Medinfar, Portugal



• Medsavorina
  Asofarma, Mexico



• Nyrin
  Korea United Pharm, Georgia



• Prevax
  Biosintética, Brazil



• Refolinon
  Pfizer, United Kingdom; Pharmacia, Luxembourg



• Reotan
  Medicus, Greece



• Rescuvolin
  Chemipharm, Greece; Combiphar, Indonesia; Med, Turkey; Medac, Germany; Medac, Luxembourg; Pharmachemie, Bangladesh; Pharmachemie, Indonesia; Pharmachemie, Iceland; Pharmachemie, Sri Lanka; Pharmachemie, Malaysia; Pharmachemie, Peru; Pharmachemie, Poland; Pharmachemie, Taiwan; Teva, Belgium



• Ribofolin
  Hikma, Germany



• Sanifolin
  Esseti Farmaceutici, Ethiopia



• Tecnovorin
  Tecnofarma, Peru; Zodiac, Brazil



• Tonofolin
  Teofarma, Italy



• Uzel
  Taiho Yakuhin, Japan



• Abic Leucovorin
  Teva Pharmaceuticals, South Africa



• Calcifolin
  Ibirn, Italy



• Calcio Folinato Sandoz
  Sandoz, Italy



• Calcium Folinate Stada
  Cell Pharm, Bulgaria



• Calciumfolinat Ebewe
  Ebewe, Czech Republic; Ebewe, Slovenia



• Calciumfolinat Hexal
  Hexal, Germany



• Calciumfolinat Meda
  Meda, Sweden



• Calciumfolinat-GRY
  Teva-Gry, Germany



• Calfolex
  Sirton Pharmaceuticals, Italy



• Calinat
  Aesculapius, Italy



• Ecofol
  Ecobi, Italy



• Foli-cell
  Cell pharm, Germany



• Folinezuur EuroCept
  EuroCept, Netherlands



• Folinezuur Sandoz
  Sandoz, Netherlands



• Folinoral
  Therabel, France



• Lederfolat
  Teofarma, Germany



• Leucovorin Ca Lachema
  Pliva, Czech Republic; Pliva-Lachema, Slovakia



• Leucovorin Lederle
  Wyeth, Czech Republic; Wyeth, Greece



• Leucovorin
  Wyeth, Germany



• Leucovorina
  Bestpharma, Chile



• Leucovorine Abic
  Sandoz, Netherlands



• Leucovorine Teva
  Teva, Netherlands



• Neofolin
  NeoCorp, Germany



• Prefolic
  Zambon, Italy



• Rescuvolin
  Pharmachemie, Netherlands



• Sanifolin
  Fargim, Italy



• Sulton
  Geymonat, Italy

International Drug Name Search

Glossary

BAN	British Approved Name
DCIT	Denominazione Comune Italiana
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
SPC	Summary of Product Characteristics (UK)
WHO	World Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

Isorbid

Isorbid may be available in the countries listed below.

Ingredient matches for Isorbid

Isosorbide Dinitrate

Isosorbide Dinitrate is reported as an ingredient of Isorbid in the following countries:

• Mexico

International Drug Name Search

Glibil

Glibil may be available in the countries listed below.

Ingredient matches for Glibil

Glibenclamide

Glibenclamide is reported as an ingredient of Glibil in the following countries:

• Bahrain


• Egypt


• Iraq


• Jordan


• Kuwait


• Lebanon


• Libya


• Oman


• Qatar


• Saudi Arabia


• Sudan


• Syria


• United Arab Emirates


• Yemen

International Drug Name Search

Azasetron

Scheme

Rec.INN

CAS registry number (Chemical Abstracts Service)

0123040-69-7

Chemical Formula

C17-H20-Cl-N3-O3

Molecular Weight

349

Therapeutic Categories

Antiemetic

Serotonin antagonist

Chemical Names

(+/-)-6-Chloro-3,4-dihydro-4-methyl-3-oxo-N-3-quinuclidinyl-2H-1,4-benzoxazine-8-carboxamide (WHO)

(+/-)-N-(3-Chinuclidinyl)-6-chlor-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazin-8-carboxamid (IUPAC)

N-1-azabicyclo(2.2.2)oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide

Foreign Names

• Azasetronum (Latin)
• Azasetron (German)
• Azasétron (French)
• Azasetron (Spanish)

Generic Names

• Nazasetron (OS: JAN)
• EP 313393 (IS)
• US 4892872 (IS)
• Azasetron Hydrochloride (OS: JAN)
• Y 25130 (IS: Yoshitomi)

Brand Names

• Serotone
  Japan Tobacco, Japan; Taiho Yakuhin, Japan; Torii Yakuhin, Japan

International Drug Name Search

Glossary

IUPAC	International Union of Pure and Applied Chemistry
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
WHO	World Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

Penicilina G Benzatina L. CH

Penicilina G Benzatina L.CH. may be available in the countries listed below.

Ingredient matches for Penicilina G Benzatina L.CH.

Benzylpenicillin

Benzylpenicillin benzathine (a derivative of Benzylpenicillin) is reported as an ingredient of Penicilina G Benzatina L.CH. in the following countries:

• Chile

International Drug Name Search

Calcar

Calcar may be available in the countries listed below.

Ingredient matches for Calcar

Calcium Carbonate

Calcium Carbonate is reported as an ingredient of Calcar in the following countries:

• Italy

International Drug Name Search

Helpocerin

Helpocerin may be available in the countries listed below.

Ingredient matches for Helpocerin

Cycloserine

Cycloserine is reported as an ingredient of Helpocerin in the following countries:

• Romania

International Drug Name Search

Parasitex EFS

Parasitex EFS may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Parasitex EFS

Dimpylate

Dimpylate is reported as an ingredient of Parasitex EFS in the following countries:

• Germany

International Drug Name Search

Microbac

Microbac may be available in the countries listed below.

Ingredient matches for Microbac

Ofloxacin

Ofloxacin is reported as an ingredient of Microbac in the following countries:

• Ecuador

International Drug Name Search